Biol
Trace Elem Res. 2004 Feb; 96(1-3): 247-54. |
Prévention par le zinc de dégâts incités
électromagnétiquement au testicule de rat et tissus de reins.
Zinc
prevention of electromagnetically induced damage to rat testicle and kidney
tissues.
Ozturk A, Baltaci AK, Mogulkoc R, Oztekin E.
Department of Urology, Meram Medical Faculty, Selcuk University, Konya, Turkey.
The aim of this study was to investigate the extent of lipid peroxidation when
zinc is administered to rats periodically exposed to a 50-Hz electromagnetic
field for 5 min at a time over a period of 6 mo. Twenty-four Sprague-Dawley
adult male rats were subdivided in groups of eight animals each. Group 1 served
as untreated controls, group 2 was exposed to an electromagnetic field but
received no additional treatment, and group 3 was exposed to electromagnetic
radiation and treated with 3-mg/kg daily intraperitoneal injections of zinc
sulfate. The erythrocyte glutathione activity (GSH) and the plasma, testicle,
and kidney tissue levels of zinc (Zn) and of malondialdehyde (MDA) were
measured in all of the animals. The plasma and testicle MDA levels in group 2
were higher than those in groups 1 and 3, with group 3 values significantly
higher than those in group 1 (p<0.001). The kidney MDA levels in group 2
were higher than in groups 1 and 3 (p<0.001). The erythrocyte GSH level was
lower in group 2 than in groups 1 and 3, with group 1 significantly lower than
group 3 (p<0.001). In testicle and kidney tissues, the GSH levels in group 1
were lower than for groups 2 and 3, with group 2 significantly lower than group
3 (p<0.001) The plasma zinc levels were highest in group 3, followed by
group 1 and group 2, which showed the lowest value (p<0.001). These results
indicate that testicle and kidney tissue damage caused by periodic exposure to
an electromagnetic field are ameliorated or prevented by zinc supplementation.